Diagnostic criteria for APS

Clinical and laboratory criteria for antiphospholipid syndrome

At least one clinical and one laboratory criterion must be must be present for diagnosis:-

Category Criteria
Clinical
  1. Thrombosis
      • ≥ 1 episodes of arterial, venous or small vessel thrombosis, OR
  2. Pregnancy morbidity
      • ≥ 1 unexplained deaths of a morphologically-normal fetus at or beyond week 10 of gestation, OR
      • ≥ 1 pre-term births of a morphologically normal neonate before week 34 of gestation because of: (i) eclampsia or severe pre-eclampsia, OR (ii) recognized features of placental insufficiency , OR
      • ≥ 3 unexplained consecutive spontaneous miscarriages before week 10 of gestation, provided maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal causes are excluded
Laboratory
  1. Lupus anticoagulant present in plasma, on ≥ 2 occasions ≥ 12 weeks apart, OR
  2. Anticardiolipin antibody of IgG and/or IgM isotype in serum or plasma, present in medium or high titre (> 40GPL units or MPL units, or > the 99th centile), on ≥ 2 occasions, ≥ 12 weeks apart, OR
  3. Anti-b2–glycoprotein I antibody of IgG and/or IgM isotype in serum or plasma (titre > 99th centile), present on ≥ 2 occasions ≥ 12 weeks apart

References

  1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4: 295–306
  2. Asherson RA, Cervera R, de Groot PG, Erkan D, Boffa MC, Piette JC st al. Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus 2003; 12: 530–4
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