Answers for Q NO 44-47
44 = [2]
Antithymocyte globulin (ATG) is an antibody preparation derived from rabbits or horses hyperimmunized with human thymocytes, which is used to prevent or treat acute cellular rejection after solid organ transplantation and as a therapy of acute aplastic anemia. Antithymocyte globulin is a hyperimmune globulin preparation made from plasma of rabbits or horses that have been immunized with human thymocytes or T cells. ATG is given by infusion only and leads to a rapid decrease in circulating T cells and lymphopenia.
Brand Names = Thymoglobulin (rabbit ATG) and Atgam (horse ATG).
Rabbit ATG is more potent than horse ATG and is used to reduce acute Graft versus Host (aGVH) disease in recipients receiving ALLO HSCT.
In aplastic anemia Horse ATG is preffered over rabbit ATG.
The standard dose of horse ATG in APLASTIC ANEMIA is 40 mg/Kg/day for 4-5 days.
45 = [2]
46 = [3]
The modified Camitta criteria are used to assess severity of AA (If Absolute neutrophil count in diagnosed AA patient is less than 200 / micoro litre than it is called as Very severe AA (See image below)
47 = [3] ATG + Cyclosporine + Eltrombopag
Triple Therapy in Aplastic anemia consists of two immunosuppressive agents ie ATG + CYCLOSPORINE along with Eltrombopag (stem cell stimulant)