Answer 54 = [2] Dxorubicin
Doxorubicin (Anthracycline)
Myelosuppression = Dose-limiting toxicity with leukopenia more common than thrombocytopenia or anemia.
Cardiotoxicity = Cummulative Dose-limiting toxicity
[1] Acute form presents within the first 2–3 days as arrhythmias and/or conduction abnormalities, EKG changes, pericarditis, and/or myocarditis.
[2] Chronic form results in a dose-dependent, dilated cardiomyopathy associated with congestive heart failure. Risk increases when cumulative doses are greater than 450 mg/m2.
The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other indirect pathways.