Answer 59 = [1]
CISPLATIN
Class = Platinum analog
Mechanism = Covalently binds to DNA with preferential binding to the N-7 position of guanine and adenine to produce cross-links.
Toxicity
Nephrotoxicity = Dose-limiting toxicity in up to 35%–40% of patients. Effects on renal function are dose-related and usually observed at 10–20 days after therapy.
Neurotoxicity usually in the form of peripheral sensory neuropathy. Paresthesias and numbness in a classic stocking-glove pattern. Tends to occur after several cycles of therapy and risk increases with cumulative doses.
Prevention of Nephrotoxicity
Patients must be hydrated before, during, and postdrug administration.