Q61-70 Basics of stem cell transplantation.
61. Which of the following is a low expression HLA antigen ?
[1] HLA A
[2] HLA B
[3] HLA DRB1
[4] HLA DQB1
62. 8/8 Match Donor excludes matching at which of the following HLA Loci ?
[1] HLA A
[2] HLA B
[3] HLA DRB1
[4] HLA DQB1
63.10/10 Match Donor excludes matching at which of the following HLA Loci ?
[1] HLA A
[2] HLA DRB1
[3] HLA DQB1
[4] HLA DPB1
Answers
61 = [4]
62 = [4]
63 = [4]
HLA matching is the most relevant factor when choosing a donor.
HLA antigens are either “high expression” such as HLA‐A, B, C (class I), DRB1 (class II), or “low expression” such as DQB1, DPB1, and DRB3/4/5 (all class II).
The “high expression” antigens play a pivotal role in the transplant setting because of high antigen density on the cells.
HLA matching at the allele level of HLA‐A, B, C and DRB1 (8 alleles) is done to see for 8/8 match.
HLA matching at the allele level of HLA‐A, B, C DRB1 and DQB1 (10 alleles) is done to see for 10/10 match.
Read Basics of HLA Typing here [READ]