Reply To: NEET SS Clinical Hematology 2020 Telegram Group Discussion MCQs

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64. In Allo HSCT the donor derived T cells mediate:-
[1] Engraftment
[2] Immune reconstitution
[3] Graft vs host disease
[4] All of these

Answer = [4]
The CD34+ cell dose is the primary determinant of successful engraftment. However, other components (in particular, the T­cells) play pivotal roles in transplant outcomes.

T­-cells mediate the following four immunological processes:
1 Engraftment
2 Immune reconstitution to prevent infection
3 Graft versus ­tumor (GvT) effect to prevent relapse
4 Graft ­versus­ host ­disease (GvHD)