64. In Allo HSCT the donor derived T cells mediate:-
[1] Engraftment
[2] Immune reconstitution
[3] Graft vs host disease
[4] All of these
Answer = [4]
The CD34+ cell dose is the primary determinant of successful engraftment. However, other components (in particular, the Tcells) play pivotal roles in transplant outcomes.
T-cells mediate the following four immunological processes:
1 Engraftment
2 Immune reconstitution to prevent infection
3 Graft versus tumor (GvT) effect to prevent relapse
4 Graft versus host disease (GvHD)