67. In BMT setting, recipient with blood group O and donor with blood group A, B or AB is regarded as ?
[1] Minor mismatch
[2] Major mismatch
[3] Compatible
[4] None of these
Answer = [2]
ABO blood type matching is not required for a successful transplant. However, ABO mismatching can result in complications.
Donor/recipient matching are either compatible or mismatched (major, minor or bi‐directional).
Major and bi‐directional (major and minor) mismatches are best avoided, if possible.
ABO major mismatch carries risk of two complications:
[1] Acute hemolysis
[2] Delayed erythroid engraftment and pure red cell aplasia
ABO minor mismatch carries risk of following complications:
[1] Passenger lymphocyte syndrome (PLS)
[2] Delayed hemolysis