71. Glucksberg-Seattle criteria (GSC) is used for grading of :-
[1] Acute GVHD
[2] Chronic GVHD
[3] Engraftment syndrome
[4] Graft vs Leukemia effect
Answer = [1] Acute graft-versus-host disease (AGVHD) severity is usually graded (grades 0-IV) by the pattern of organ involvement using the classic Glucksberg-Seattle criteria (GSC).
NOTE >> International Bone Marrow Transplant Registry (IBMTR) developed a new Severity Index by regrouping the patterns of organ involvement into five Indexes (0-D) that appeared more predictive of transplant-related mortality (TRM) and transplant failure (TF, relapse or TRM).
72. Acute GVHD grading and staging in based on all of the following EXCEPT?
[1] Liver enzyme levels
[2] Serum bilirubin
[3] % of skin involvement
[4] Daily stool volumes
Answer = [1] Acute graft‐versus‐host disease (GvHD) is a frequent complication of allogeneic haemopoietic stem cell transplantation (HSCT) and donor lymphocyte infusions (DLI). First‐line treatment of acute GvHD is based on corticosteroids, and produce sustained responses in 50–80% of patients depending on the initial severity.
The original grading system for acute GvHD was proposed by Glucksberg et al (1974) and identified five categories of patients (grades 0, I, II, III, IV). It is known as the Glucksberg‐Seattle criteria (GSC) and it is based on the degree of skin, liver and gut involvement (skin rash, total serum bilirubin and diarrhoea volume), together with a subjective assessment of clinical status.
73. Ann Arbor biomarker risk score for Acute GVHD is based on estimation of levels of :-
[1] TNFR1
[2] REG3 Alpha
[3] ST2
[4] All of these
Answer = [4] All of these: Ann Arbor biomarker risk score for Acute GVHD is based on concentrations of three recently validated biomarkers (TNFR1, ST2, and REG3α) to create an algorithm that computed the probability of NRM six months after GVHD onset for individual patients.
74. Drug of choice (First line agent) for treatment of acute GVHD is ?
[1] Steroid
[2] Methotrexate
[3] Ruxolitinib
[4] Cyclosporine
Answer = [1] Acute graft‐versus‐host disease (GvHD) is a frequent complication of allogeneic haemopoietic stem cell transplantation (HSCT) and donor lymphocyte infusions (DLI). First‐line treatment of acute GvHD is based on corticosteroids, and produce sustained responses in 50–80% of patients depending on the initial severity.
75. Drug of choice (First line agent) for treatment of chronic GVHD is ?
[1] Cyclosporine
[2] Steroid
[3] Ruxolitinib
[4] Methotrexate
Answer = [B] Steroid