Recombinant Factor VIIa Dosing

Recombinant Factor VIIa is indicated for:

  • Treatment of bleeding episodes and perioperative management in adults and children with hemophilia A or B with inhibitors, congenital Factor VII (FVII) deficiency, and Glanzmann’s thrombasthenia with refractoriness to platelet transfusions, with or without antibodies to platelets.
  • Treatment of bleeding episodes and perioperative management in adults with acquired hemophilia.

Dosing for bleeding in approved indications:-

Indication Dosing Recommendation
Congenital Hemophilia A or B with Inhibitors
  • 90 mcg/kg every 2 hours, adjustable based on severity of bleeding until hemostasis is achieved
  • 90 mcg/kg every 3-6 hours after hemostasis is achieved for severe bleeds
Acquired Hemophilia
  • 70-90 mcg/kg every 2-3 hours until hemostasis is achieved
Congenital Factor VII Deficiency
  • 15-30 mcg/kg every 4-6 hours until hemostasis is achieved
Glanzmann’s Thrombasthenia
  • 90 mcg/kg every 2-6 hours until hemostasis is achieved

Dosing for Peri-operative management in approved indications:-

Indication Dosing Recommendation
Congenital Hemophilia A or B with Inhibitors Minor:

  • 90 mcg/kg immediately before surgery, repeat every 2 hours during surgery
  • 90 mcg/kg every 2 hours after surgery for 48 hours, then every 2-6 hours until healing has occurred

Major:

  • 90 mcg/kg immediately before surgery, repeat every 2 hours during surgery
  • 90 mcg/kg every 2 hours after surgery for 5 days, then every 4 hours until healing has occurred
Acquired Hemophilia
  • 70-90 mcg/kg immediately before surgery and every 2-3 hours for the duration of surgery and until hemostasis is achieved
Congenital Factor VII Deficiency
  • 15-30 mcg/kg immediately before surgery and every 4-6 hours for the duration of surgery and until hemostasis is achieved
Glanzmann’s Thrombasthenia
  • 90 mcg/kg immediately before surgery and repeat every 2 hours for the duration of the procedure
  • 90 mcg/kg every 2-6 hours to prevent post-operative bleeding

NovoSeven® RT dose Complete prescribing information: Click here

 

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