| International Prognostic Score (Hasenclever Index)- Prognostic score for advanced Hodgkin lymphoma |
Sum the number of risk factors
| IPS risk factors |
|---|
| Serum albumin < 40 g/L |
| Hemoglobin < 10.5 g/dL |
| Male sex |
| Ann Arbor Stage IV |
| Age ≥ 45 years |
| White cell count ≥ 15 x109/L |
| Lymphocyte count < 0.6 x109/L |
| Determine prognosis |
|---|
| Risk factors (n) | % of patients | 5 year PFS (%) | 5 year OS(%) |
|---|---|---|---|
| 0 | 7 | 84 | 89 |
| 1 | 22 | 77 | 90 |
| 2 | 29 | 67 | 81 |
| 3 | 23 | 60 | 78 |
| 4 | 12 | 51 | 61 |
| ≥ 5 | 7 | 42 | 56 |
- Hasenclever Index is a seven-factor prognostic scoring system that predicts five-year rates of freedom from progression of disease in the range of 45 to 80 percent. Each additional factor reduced the predicted rate by about 8 percent. The prognostic score is also predictive of overall survival, and the predictive effects were reproducible in a large (partial) validation sample.
- The score was derived from a large, broadly representative, and fairly homogeneous set of data provided by 25 study groups and institutions and was developed from a multivariate analysis of survival of 4695 patients with newly-diagnosed advanced Hodgkin disease, treated with combination chemotherapies between 1983 and 1992 (click here for original article)
- The Hasenclever Index retains prognostic relevance among patients treated uniformly with ABVD/COPP or with the more intensive BEACOPP regimens.