|International Prognostic Score (Hasenclever Index)- Prognostic score for advanced Hodgkin lymphoma|
Sum the number of risk factors
|IPS risk factors|
|Serum albumin < 40 g/L|
|Hemoglobin < 10.5 g/dL|
|Ann Arbor Stage IV|
|Age ≥ 45 years|
|White cell count ≥ 15 x109/L|
|Lymphocyte count < 0.6 x109/L|
|Risk factors (n)||% of patients||5 year PFS (%)||5 year OS(%)|
- Hasenclever Index is a seven-factor prognostic scoring system that predicts five-year rates of freedom from progression of disease in the range of 45 to 80 percent. Each additional factor reduced the predicted rate by about 8 percent. The prognostic score is also predictive of overall survival, and the predictive effects were reproducible in a large (partial) validation sample.
- The score was derived from a large, broadly representative, and fairly homogeneous set of data provided by 25 study groups and institutions and was developed from a multivariate analysis of survival of 4695 patients with newly-diagnosed advanced Hodgkin disease, treated with combination chemotherapies between 1983 and 1992 (click here for original article)
- The Hasenclever Index retains prognostic relevance among patients treated uniformly with ABVD/COPP or with the more intensive BEACOPP regimens.