The Dynamic International Prognostic Scoring System (DIPSS) was developed by the IWG-MRT and it takes into account progression of disease over time and hence it can be used to evaluate prognosis as a patient’s condition in any time point of disease course. Note the fact that DIPSS uses same adverse prognostic factors as IPSS but weights them differently. In determining the risk categories, hemoglobin below 10 g/dL is given a score of 2, while the other risk factors are counted as 1.
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The 5 adverse prognostic factors included in DIPSS risk model are
- Age >65 years -1 POINT
- Constitutional symptoms -1 POINT
- Hemoglobin <10 g/dL – 2 POINT
- WBC count >25 × 109/L – 1 POINT
- Blood blasts ≥1% – 1 POINT
Prognostic groups
| Risk Category | Number of POINTS | Median survival, years |
| Low | 0 | Not Reached |
| INT-1 | 1-2 | 14.2 |
| INT-2 | 3-4 | 4.0 |
| High | 5-6 | 1.5 |
Reference:
Dynamic International Prognostic Scoring System (DIPSS) predicts progression to acute myeloid leukemia in primary myelofibrosis.
Blood (2010) 116 (15): 2857–2858. doi.org/10.1182/blood-2010-06-293415